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快速了解科研前沿动态，每天都有新想法！本内容主要对生命科学领域的一些期刊文章标题进行翻译，如果出现翻译错误请谅解。

1.Antigen-agnostic tumour tagging for CAR T cell therapy. This issue highlights the generation of T cells expressing a tumour-directed receptor constitutively and an inducible transgene, the suppression of tumour growth via the cooperative phagocytic activity of macrophages, a nanoparticle targeting myeloid-cell-rich haematopoietic organs for resolving immunoparalysis, the amphiphilic tagging of cancer cells for the universal redirection of CAR T cells against tumours, an interleukin-6-adsorbing hydrogel for the suppression of cytokine release syndrome, glycosylated antigens for the suppression of established immune responses, a fusion protein of an immunosuppressive enzyme for treating local inflammation, the transcriptomic profiling of the fate of human CAR T cells in vivo, and the microfluidic isolation of tumour-reactive lymphocytes from peripheral blood.

用于 CAR T 细胞治疗的抗原不可知肿瘤标记。本期重点介绍了组成型表达肿瘤导向受体和诱导型转基因的 T 细胞的产生、通过巨噬细胞的协同吞噬活性抑制肿瘤生长、针对富含骨髓细胞的造血器官以解决免疫麻痹问题的纳米颗粒、两亲性标签癌细胞的普遍重定向，用于对抗肿瘤的 CAR T 细胞，用于抑制细胞因子释放综合征的白细胞介素 6 吸附水凝胶，用于抑制已建立的免疫反应的糖基化抗原，用于治疗局部炎症的免疫抑制酶的融合蛋白、体内人类 CAR T 细胞命运的转录组分析，以及从外周血中微流体分离肿瘤反应性淋巴细胞。

2.A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor.

一种慢病毒载体，用于产生具有诱导型转基因和组成型表达的肿瘤靶向受体的 T 细胞。

3.Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses.

巨噬细胞对实体瘤的协同吞噬作用引发持久的抗肿瘤反应。

4.Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells.

通过将 IL-4 靶向骨髓细胞，通过训练有素的免疫力解决脓毒症引起的免疫麻痹。

5.Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR.

通过插入膜的 CAR 配体对 CAR T 细胞进行通用重定向以对抗实体瘤。

6.Suppression of cytokine release syndrome during CAR-T-cell therapy via a subcutaneously injected interleukin-6-adsorbing hydrogel.

通过皮下注射白细胞介素 6 吸附水凝胶抑制 CAR-T 细胞治疗期间的细胞因子释放综合征。

7.Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses.

合成糖基化抗原，用于对已建立的免疫反应进行抗原特异性抑制。

8.Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase.

通过半乳糖凝集素锚定的吲哚胺 2,3-双加氧酶抑制局部炎症。

9.Multiplexed transcriptomic profiling of the fate of human CAR T cells in vivo via genetic barcoding with shielded small nucleotides.

通过带有屏蔽小核苷酸的遗传条形码对人 CAR T 细胞体内命运进行多重转录组分析。

10.Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting.

通过微流体免疫磁性细胞分选从外周血中分离肿瘤反应性淋巴细胞。

快速了解科研前沿动态，每天都有新想法！本内容主要对生命科学领域的一些期刊文章标题进行翻译，如果出现翻译错误请谅解。

1.In-ear monitoring of brain states and of lactate in sweat. This issue highlights advances in the application of wearable, ingestible or implantable bioelectronic devices for the monitoring of health status, disease progression or the effectiveness of treatment. It also includes electronic scaffolds for tracking the migration of brain cells after injury, and implants that facilitate closed-loop neuromodulation in small animals.

入耳式监测大脑状态和汗液中的乳酸。本期重点介绍了可穿戴、可摄入或植入式生物电子设备在监测健康状况、疾病进展或治疗效果方面的应用进展。它还包括用于跟踪受伤后脑细胞迁移的电子支架，以及促进小动物闭环神经调节的植入物。

2.A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature.

一种无电池无线植入物，用于连续监测血管压力、流速和温度。

3.Synchronized wearables for the detection of haemodynamic states via electrocardiography and multispectral photoplethysmography.

用于通过心电图和多光谱光电体积描记法检测血流动力学状态的同步可穿戴设备。

4.A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy.

用于实时监测放射治疗的可吞咽式 X 射线剂量计。

5.A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals.

用于小动物多模式闭环神经调节的无线无电池植入物。

6.Soft and stretchable organic bioelectronics for continuous intraoperative neurophysiological monitoring during microsurgery.

柔软且可拉伸的有机生物电子学，用于显微手术期间连续的术中神经生理学监测。

7.Laminin-coated electronic scaffolds with vascular topography for tracking and promoting the migration of brain cells after injury.

具有血管拓扑的层粘连蛋白涂层电子支架，用于跟踪和促进损伤后脑细胞的迁移。

8.A wireless patch for the monitoring of C-reactive protein in sweat.

用于监测汗液中 C 反应蛋白的无线贴片。

9.In-ear integrated sensor array for the continuous monitoring of brain activity and of lactate in sweat.

耳内集成传感器阵列，用于连续监测大脑活动和汗液中的乳酸。

10.Stretchable ultrasonic arrays for the three-dimensional mapping of the modulus of deep tissue.

用于深层组织模量三维映射的可拉伸超声阵列。

快速了解科研前沿动态，每天都有新想法！本内容主要对生命科学领域的一些期刊文章标题进行翻译，如果出现翻译错误请谅解。

1.Functionally distinct T cells in viscoelastically dissimilar matrices. This issue highlights that interstitial-fluid shear stresses lower blood pressure in individuals with hypertension, that functionally distinct T cell populations can be generated from extracellular matrices with different viscoelasticity, a method for rapid single-cell physical phenotyping, a Cas12a-based assay for the detection of cellular traction forces, that elevated tissue-scale forces can drive foreign-body responses to implants, that advanced glycation end-products can mediate the crosslinking of liver extracellular matrix in cirrhosis, that bone-matrix mineralization induces a quiescent phenotype in breast cancer cells, an intravital method for measuring solid stresses in tumours, electro-metabolic coupling in vascularized cardiac organoids, and that microtopography can influence chromatin conformation and osteogenic differentiation in human mesenchymal stromal cells.

粘弹性不同基质中功能不同的 T 细胞。本期强调间质液剪切应力可降低高血压患者的血压，功能不同的 T 细胞群可以从具有不同粘弹性的细胞外基质中产生，这是一种快速单细胞物理表型分析方法，是一种基于 Cas12a 的检测方法。检测细胞牵引力，升高的组织尺度力可以驱动对植入物的异物反应，晚期糖基化终产物可以介导肝硬化中肝细胞外基质的交联，骨基质矿化诱导乳腺癌中的静止表型细胞，一种测量肿瘤固体应力的活体方法，血管化心脏类器官中的电代谢耦合，以及微形貌可以影响人间充质基质细胞的染色质构象和成骨分化。

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2.Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans.

垂直摆动头部运动引起的间质液剪切应力可降低高血压大鼠和人类的血压。

3.Generation of functionally distinct T-cell populations by altering the viscoelasticity of their extracellular matrix.

通过改变细胞外基质的粘弹性来生成功能不同的 T 细胞群。

4.Rapid single-cell physical phenotyping of mechanically dissociated tissue biopsies.

机械分离组织活检的快速单细胞物理表型分析。

5.Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand.

通过力触发 Cas12a 介导的荧光报告链催化裂解来检测细胞牵引力。

6.Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells.

异速缩放组织力通过 Rac2 激活的骨髓细胞驱动对植入物的病理性异物反应。

7.Advanced glycation end-products as mediators of the aberrant crosslinking of extracellular matrix in scarred liver tissue.

高级糖基化终产物作为疤痕肝组织中细胞外基质异常交联的介质。

8.Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer.

骨基质矿化抑制整合素介导的机械信号传导和乳腺癌的转移进展。

9.Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission.

肿瘤中固体应力的活体测量揭示了长度尺度和微环境依赖性的力传递。

10.Electro-metabolic coupling in multi-chambered vascularized human cardiac organoids.

多腔血管化人心脏类器官中的电代谢耦合。

11.Chromatin reprogramming and bone regeneration in vitro and in vivo via the microtopography-induced constriction of cell nuclei.

通过微形貌诱导的细胞核收缩进行体外和体内染色质重编程和骨再生。

快速了解科研前沿动态，每天都有新想法！本内容主要对生命科学领域的一些期刊文章标题进行翻译，如果出现翻译错误请谅解。

1.Optoacoustically detected skin angiopathy correlates with diabetes stage. This issue highlights strategies towards the simplification of the operation of diagnostic assays for point-of-care use. It also describes plasmonically active fluorescent gold nanorods as antibody-conjugated labels for enhancing the sensitivity of lateral-flow assays, the fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients, that the growth of aortic aneurysms can be predicted via a physiomarker describing a transition from stable blood flow to unstable aortic fluttering, that RNAs derived from transposable elements are enriched in the cell-free transcriptome of patients with cancer, and that dermal features derived from optoacoustic tomograms can be used to correlate microangiopathy phenotypes with diabetes stage.

光声检测到的皮肤血管病与糖尿病阶段相关。本期重点介绍了简化床旁诊断分析操作的策略。它还描述了等离激元活性荧光金纳米棒作为抗体缀合标记，用于增强侧向流动测定的灵敏度，注射吲哚菁绿的荧光寿命作为患者实体瘤的通用标记物，可以通过以下方式预测主动脉瘤的生长一种描述从稳定血流向不稳定主动脉扑动转变的生理标志物，源自转座元件的 RNA 在癌症患者的无细胞转录组中富集，源自光声断层扫描的皮肤特征可用于将微血管病表型与糖尿病相关联阶段。

2.Ultrasensitive lateral-flow assays via plasmonically active antibody-conjugated fluorescent nanoparticles.

通过等离子体活性抗体缀合荧光纳米颗粒进行超灵敏侧流测定。

3.Detection of viral RNAs at ambient temperature via reporter proteins produced through the target-splinted ligation of DNA probes.

通过 DNA 探针的靶夹板连接产生的报告蛋白在环境温度下检测病毒 RNA。

4.A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs.

一种基于 Cas12 的一锅等温测定法，用于灵敏检测 microRNA。

5.Detection of low-frequency mutations in clinical samples by increasing mutation abundance via the excision of wild-type sequences.

通过切除野生型序列来增加突变丰度，检测临床样本中的低频突变。

6.Blood–wall fluttering instability as a physiomarker of the progression of thoracic aortic aneurysms.

血壁扑动不稳定性作为胸主动脉瘤进展的生理标志。

7.Profiling of repetitive RNA sequences in the blood plasma of patients with cancer.

癌症患者血浆中重复 RNA 序列的分析。

8.Multiplexed discrimination of SARS-CoV-2 variants via plasmonic-enhanced fluorescence in a portable and automated device.

在便携式自动化设备中通过等离子体增强荧光对 SARS-CoV-2 变体进行多重区分。

9.Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients.

注射吲哚菁绿的荧光寿命作为患者实体瘤的通用标记物。

10.Dermal features derived from optoacoustic tomograms via machine learning correlate microangiopathy phenotypes with diabetes stage.

通过机器学习从光声断层扫描得出的皮肤特征将微血管病表型与糖尿病阶段相关联。